[Nekromantis]

Hi,

I need a recipe how to make a 2-(Chloromethyl)pyridine or 2-(bromomethyl)pyridine. I searched in internet but I don't found nothing special.  Someone help me?

[discodermolide]

You are a student of organic chemistry, according to the statement at the bottom of your posts. Have you no access to a university library?
Have you any ideas how one might make this (these compounds)?

[Nekromantis]

I went back to my family home for the weekend and now i don't have a access to mu university datbase. I Found one website:

http://www.patentgenius.com/patent/4221913.html

but my promoter of my master science thesis want a article.

[kriggy]

You dont have distant acces to your library? You should ask about it, its very handy
Anyway, I´ve done this few weeks ago so I think I can help you:
using procedure from Bioorganic and Medicinal Chemistry,  2009 ,  vol. 17,  # 10   p. 3604 - 3617

5g of PyCHOH was dissolved in CHCl₃ and cooled to 0°C. 27g of SOCl₂ was added slowly so the temperature didnt rise over 10°C and the colour changed to  yellow-gree. After addition of all SOCl₂ the mixture was stirred at RT for about 45 minutes. After 45 mins the mixture was basified to pH~8 by Na₂CO₃. After that the solution was extracted by 3x50ml of CHCl₃. Organic layer was washed with 3x50 ml of water and dried over Na₂SO₄. After evaporation of solvent the red solution appeared and red crystals started to crystalize.

note: I have some impurities in my product due to impurities in starting material which i wasnt aware of when I started the reaction. So it is possible that your product will have different colour

[Nekromantis]

kriggy thank you very much!