[derjewnfwornv]

Biochemist Sanger, found DNA structure, has lost his life.. Everybody, please share your feeling about him here..

[Babcock_Hall]

Frederick Sanger was responsible for finding a way to sequence polypeptides.  Later he found a way to sequence DNA, the basic idea of which (using dideoxynucleoside triphosphates to bring about chain termination) is still used today.  We tend to take DNA sequencing for granted, but it is huge in the sense of how much other work it enabled.  He won two Nobel prizes, a relatively rare feat.

[Yggdrasil]

Sanger's contribution to protein biochemistry is much greater than figuring out how to sequence polypeptides.  At the time Sanger was doing his work, it wasn't known whether proteins had a defined sequence or whether the arrangement of amino acids in the polypeptide were somewhat semi-random.  From Sanger's 1958 Nobel Lecture:

In 1943 the basic principles of protein chemistry were firmly established.
It was known that all proteins were built up from amino acid residues bound
together by peptide bonds to form long polypeptide chains. Twenty different
amino acids are found in most mammalian proteins and by analytical
procedures it was possible to say with reasonable accuracy how many residues
of each one was present in a given protein. Practically nothing, however,
was known about the relative order in which these residues were
arranged in the molecules. This order seemed to be of particular importance,
since although all proteins contained approximately the same amino acids
they differed markedly in both physical and biological properties. It was thus
concluded that these differences were dependent on the different arrangement
of the amino-acid residues in the molecules. Although very little was
known about amino-acid sequence, there was much speculation in this field.
The most widely discussed theory was that of Bergmann and Niemann who
suggested that the amino acids were arranged in a periodic fashion, the residues
of one type of amino acid occurring at regular intervals along the
chain. On the other extreme there were those who suggested that a pure
protein was not a chemical individual in the classical sense but consisted of a
random mixture of similar individuals.

(http://www.nobelprize.org/nobel_prizes/chemistry/laureates/1958/sanger-lecture.html)

The ability to sequence a protein and demonstrate that it consists of a single population with a defined sequence of amino acids greatly changed the way scientists thought about proteins, and was an important step in developing our modern paradigms about protein structure and function.