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Topic: Is a Long-Chain/Medium-Chain Triglyceride "hybrid" possible?  (Read 2264 times)

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Offline prodigee411

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Is a Long-Chain/Medium-Chain Triglyceride "hybrid" possible?
« on: January 10, 2014, 07:02:29 AM »
Long-Chain Triglycerides (ie Olive Oil) and Medium-Chain Tryglycerides (ie Coconut Oil) are absorbed differently;  LCT are absorbed/processed by the lymphatic system and bypass the liver, while MCT are absorbed through the intestinal tract/liver and eventually into the bloodstream. 
Recognizing these key differences, how would a solution comprised of equal parts mixed Coconut Oil and Olive Oil change in molecular structure and ultimately how would this new structure would be processed by the body?
Secondly,  in an attempt to combat conditions that cause excessive inflammation throughout the entire body (psoriasis,rheumatoid arthritis, others), which type of structure (long, short or hybrid) would most effectively deliver drugs with poor bio-availability(lipophilic).
I have a strong interest in solid-lipid nanoparticle research and would greatly appreciate any feedback.  Thanks.
« Last Edit: January 10, 2014, 07:12:41 AM by prodigee411 »

Offline TheUnassuming

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Re: Is a Long-Chain/Medium-Chain Triglyceride "hybrid" possible?
« Reply #1 on: January 10, 2014, 09:23:33 AM »
This sounds a lot like a homework question and it looks like you need to do more leg work. 
Looking at the structure of a triglyceride do you think its synthetically feasible to make a hybrid?
Making a solution of the two oils will not create a molecular hybrid in the sense I think you are thinking, though it will produce different macro lipid structures.  To answer your first question you need to read more about exactly how the body absorbs and distributes fatty acids. 
Read up on the topic of prodrugs to answer your last question, there are a number of great review papers out there on the topic. 
When in doubt, avoid the Stille coupling.

Offline Babcock_Hall

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Re: Is a Long-Chain/Medium-Chain Triglyceride "hybrid" possible?
« Reply #2 on: January 10, 2014, 10:06:39 AM »
It is a forum rule that you must show your attempt before anyone can help you.

Offline Enthalpy

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Re: Is a Long-Chain/Medium-Chain Triglyceride "hybrid" possible?
« Reply #3 on: January 11, 2014, 03:13:09 PM »
Both a mixture of triglycerides and a triglyceride of unequal length fatty are possible to make. Which one do you want?

About the fate of triglycerides in the body, a biology forum might bring you more information.

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