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Topic: How to purify this compound? (Structure uploaded inside) ='(  (Read 1913 times)

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Offline karlyip

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How to purify this compound? (Structure uploaded inside) ='(
« on: March 17, 2014, 09:04:25 AM »
I synthesised small amount of this beta-lactams (see the figure below)

But I have no idea to purify this compound unless using preparative column. However, our laboratory have no such kind of column and the compound is urgent for experiment. Is there any other way to purify this compound?

Thanks so much!!!
« Last Edit: March 17, 2014, 10:51:34 AM by karlyip »
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Offline discodermolide

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Re: How to purify this compound? (Structure uploaded inside) ='(
« Reply #1 on: March 17, 2014, 09:13:05 AM »
Crystallisation.
Either directly or make a salt of the amine.

How much material do you have and do you have an idea of it's purity at the moment?
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Offline karlyip

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Re: How to purify this compound? (Structure uploaded inside) ='(
« Reply #2 on: March 17, 2014, 09:55:57 AM »
No much, about 0.3g, purity around 80%
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Offline discodermolide

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Re: How to purify this compound? (Structure uploaded inside) ='(
« Reply #3 on: March 17, 2014, 10:07:14 AM »
Just crystallise it then.
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Offline orgopete

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Re: How to purify this compound? (Structure uploaded inside) ='(
« Reply #4 on: March 17, 2014, 11:05:56 AM »
Complete reaction of starting materials combined with removal of non-basic impurities as suggested by Disco should improve purity and improve crystallization.
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