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Topic: 3-methyl-butyrolactone  (Read 6349 times)

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sohushi

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3-methyl-butyrolactone
« on: March 22, 2006, 02:40:42 AM »
how to make the compound
wait  for  your repay
« Last Edit: March 22, 2006, 10:53:58 PM by sohushi »
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Offline AWK

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Re:3-methyl-butyrolactone
« Reply #1 on: March 22, 2006, 03:35:36 AM »
Start from sketch of its structure
« Last Edit: March 22, 2006, 03:38:49 AM by AWK »
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Offline Albert

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Re:3-methyl-butyrolactone
« Reply #2 on: March 22, 2006, 01:21:29 PM »
From which compound(s) do you have to start?
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Offline HP

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Re:3-methyl-butyrolactone
« Reply #3 on: March 22, 2006, 02:10:04 PM »
Butyrolactone can be easily prepared from tetrahydrofuran (THF) when oxidize with Ca-hypochlorite ( Ca(OCl)2) or HNO3 as oxidizing agents.
Well may be if you start from methyl-THF...For the synthesis this you may start from furfural ( produced commercially by the acid hydrolysis of pentosan polysaccharides from non-food residues of food crops and wood wastes) then convert aldehyde CHO group to CH3(now i dont have exact idea this reaction) and of course hydrogenation of the double bonds :) Hope this compound isn't drug precursor for bad aims!
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sohushi

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Re:3-methyl-butyrolactone
« Reply #4 on: March 22, 2006, 09:47:21 PM »
I want to start from 2-methyl-1,3-propanediol .

how can  you prepared from tetrahydrofuran (THF) when oxidize with Ca-hypochlorite ( Ca(OCl)2) or HNO3 as oxidizing agents.
 
please speak in detail .
 
do you have some reference literature .
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Offline AWK

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Re:3-methyl-butyrolactone
« Reply #5 on: March 23, 2006, 02:15:48 AM »
(17) (a) Schulz, S. Liebigs Ann. Chem. 1992, 829. (b) Kayser, M. M.;
Morand, P. Can. J. Chem. 1980, 58, 2484.
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