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Topic: Are equilibrium reactions synthetically useful?  (Read 2354 times)

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Offline davidenarb

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Are equilibrium reactions synthetically useful?
« on: August 07, 2014, 06:50:37 AM »
In organic chemistry, there are some reactions where an equilibrium are established such the formation of Acetal starting from a carbonyl compound; I found a lot of emphasis and problems regarding this section.

However, I am curious to know whether these kind of reactions are synthetically useful?

Thanks

Offline Dan

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Re: Are equilibrium reactions synthetically useful?
« Reply #1 on: August 07, 2014, 07:30:47 AM »
However, I am curious to know whether these kind of reactions are synthetically useful?

Yes, they can be very useful - acetal chemistry is extremely important in classical organic synthesis.

The system can be biased to favour one side of the equilibrium. Hint: Le Chatelier.
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Offline PhDoc

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Re: Are equilibrium reactions synthetically useful?
« Reply #2 on: August 07, 2014, 11:51:11 AM »
Acetal chemistry is a great example, and so is: (1) Fischer esterification; (2) Aldol chemistry; (3) imine formation; (4) transesterification; (5) cyanohydrin formation, etc.

Many reactions taking place in mammalian systems are equilibrium reactions.

The most important thing to understand is what constitutes an equilibrium reaction, and it's not simply " ::equil::"

If you have an intermediate or product that, when placed into the conditions of the original reaction, leads to formation of earlier intermediates and/or starting material, then you have an equilibrium process.

Think Le Chatlier's Principle, what it means, and how it can be utilized in a lab. You'll then be led to the most common "trick" not in the book.
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Offline zsinger

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Re: Are equilibrium reactions synthetically useful?
« Reply #3 on: August 08, 2014, 08:45:56 PM »
See: Dean Stark Trap, and its use in organic synthesis.
        -Zack
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