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Topic: azide and AlCl3  (Read 3581 times)

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netscape

  • Guest
azide and AlCl3
« on: March 16, 2006, 01:36:57 AM »

I need to carry out a Friedel Crafts reaction with AlCl3 on a molecule that has an azido (N3) group somewhere on the molecule.
Is there going to be a compatibility issue?  I did a Scifinder search of reactions involving R-N3 and AlCl3, and I haven't found
a single example in which the N3 group was preserved.  Instead, they all involve the use of AlCl3 to reduce N3 to NH2, in the presence of some
hydride source of course.  

Does anyone have experience running an FC reaction without disturbing the azido functionality?

SoFTiCE

  • Guest
Re:azide and AlCl3
« Reply #1 on: April 01, 2006, 09:31:45 AM »
N3 group is very unstable and this because you should obtain N3 group after F-K reaction. You haven't other way.

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