November 25, 2024, 06:32:46 AM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: effect of trifluoromethyl group on reactivity of pimary amine  (Read 2527 times)

0 Members and 1 Guest are viewing this topic.

Offline kevalb56

  • New Member
  • **
  • Posts: 7
  • Mole Snacks: +0/-1
effect of trifluoromethyl group on reactivity of pimary amine
« on: January 29, 2015, 08:36:30 AM »
hello sir,
   I try to couple primary amine (ortho to -CF3 group)with aliphatic chloro in sodium hydride(solvent:-Toluene overnight reflux),(DMF overnight heating).but in both solvents reaction can't moved more than 20%.so please give me advice fast what can I do to complete reaction?
Logged

Offline TheUnassuming

  • Chemist
  • Full Member
  • *
  • Posts: 461
  • Mole Snacks: +48/-1
Re: effect of trifluoromethyl group on reactivity of pimary amine
« Reply #1 on: January 29, 2015, 09:36:29 AM »
Primary amine=benzylamine?
How are you monitoring the reaction?
I wouldn't use DMF, especially if you are heating it up since DMF has the tendency to decompose when heated.
Logged
When in doubt, avoid the Stille coupling.
Pages: [1]   Go Up
« previous next »
Sponsored Links