I am reading a paper right now regarding the effect of stains of PCSK9 levels.
"In our study the average increase in plasma PCSK9 was greater following fibrate therapy (17%) than following statin therapy (7%).
In both fibrate and statin cohorts, the inverse correlation between changes in plasma PCSK9 and LDLC was significant in men, and not in women, although the numbers of women were low and therefore may not have been significantly powered. "
I am a bit confused. So since an inverse relationship is observed, as PCSK9 levels increase, LDL-C levels decrease?
I expected that as PCSK9 increased, it would lead to increased LDL-R degradation leading to an increase is LDL-C levels...
thanks