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Topic: side reaction in the amide coupling of acid containing cyano group  (Read 1538 times)

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Offline anupree86

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side reaction in the amide coupling of acid containing cyano group
« on: April 22, 2016, 06:41:56 AM »
Hi everyone,

i tried amide coupling of  acid containing cyano group with EDCI and HObt conditions. Is there any possibility of side reaction through cyano group.

Thanks.
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Offline Doc Oc

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Re: side reaction in the amide coupling of acid containing cyano group
« Reply #1 on: April 25, 2016, 04:11:40 PM »
No, the cyano group will not interfere with a peptide coupling
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