November 01, 2024, 09:16:00 PM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: Synthesis of amides with EDC and HOBt  (Read 9933 times)

0 Members and 1 Guest are viewing this topic.

Offline DavidW

  • Chemist
  • Regular Member
  • *
  • Posts: 21
  • Mole Snacks: +0/-0
Synthesis of amides with EDC and HOBt
« on: June 12, 2006, 10:15:00 AM »

I'm planning to run some coupling reactions with carboxylic acid and amine, using EDC and HOBt, to make amides.  I was wondering if the reaction would still work if I were to use carboxylic acid salt, instead of the neutral carboxylic acid? 
Logged

Offline HP

  • Chemist
  • Full Member
  • *
  • Posts: 350
  • Mole Snacks: +33/-5
  • Gender: Male
Re: Synthesis of amides with EDC and HOBt
« Reply #1 on: June 13, 2006, 01:29:47 PM »
Nope the activation mechanism with carbodiimides requier COOH and COO:-Na+ cant effectively activate it.


« Last Edit: June 13, 2006, 02:25:03 PM by Borek »
Logged
xpp
Pages: [1]   Go Up
« previous next »
Sponsored Links