[ismailcelik]

Hello dear friends!

I have a question about a reaction route in my thesis. I am synthesized thiosemicarbazide then in alkaline/acidic medium is synthesized from thiosemicarbazide to triazoles/thiadiazoles.However alkyl isotiyosyanate as methyl/ethyl/cyclohexyl can be thiosemicarbazide,  2-pieridino ethyl and 2-(4-morpholino) ethyl isothiosyanate isn't thiosemicarbazide and is directly transforming triazole. But I don't want to direct this cyclization. Because thiazdiazoles obtain from that thiosemicarbazides.I want to get morpholino and piperidino ethyl thiadiazole. May are you doing advice this difficult problem.

thanks everone !

[rolnor]

Maybe in the first step you could try using hydrochloride of the hydrazide to make it less reactive?