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Topic: Triphenylphosphineoxide  (Read 8526 times)

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Offline Johnny

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Triphenylphosphineoxide
« on: September 18, 2006, 12:33:45 PM »
I am using triphenylphosphineoxide as a reagent, and the reaction works nice but I can´t seem to get rid of the triphenylphosphineoxide by using chromatography as it has a similar retention as my product. So I just wondered if anyone got some nice way to get rid of it.
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Offline Borek

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Re: Triphenylphosphineoxide
« Reply #1 on: September 18, 2006, 12:44:56 PM »
Quote from: Johnny on September 18, 2006, 12:33:45 PM
it has a similar retention as my product

Regardless of solvent/column filling?
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Offline Johnny

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Re: Triphenylphosphineoxide
« Reply #2 on: September 18, 2006, 12:52:03 PM »
I have only been trying heptane/EtOAc solutions, but my product is not very UV active and very close and sometimes under the big blob of triphenylphosphine oxide
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Offline russellm72

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Re: Triphenylphosphineoxide
« Reply #3 on: September 18, 2006, 02:28:21 PM »
If your compound dissolves in ether you could triturating the Ph3PO out while chilling but...

Ever thought of trying polymer supported triphenylphosphine?

I agree though try other solvent combinations that may effect better resolution. Perhaps toluene-EtOAc and I am sure you can find a stain to locate your product.

R.
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Offline Mitch

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Re: Triphenylphosphineoxide
« Reply #4 on: September 19, 2006, 01:34:16 AM »
Triphenylphosphine is very hard to get completely out from a product. I've sometimes seen it in my NMRs after a couple of reaction steps.
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Offline mike

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Re: Triphenylphosphineoxide
« Reply #5 on: September 19, 2006, 02:06:32 AM »
I got a nice crystal structure of triphenylphosphine oxide once.
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Offline HP

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Re: Triphenylphosphineoxide
« Reply #6 on: September 19, 2006, 12:54:19 PM »
Also if your product is water soluble then you can extract it with water or buffer solution without (Ph)3PO which is water insoluble...
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Offline firassh2000

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Re: Triphenylphosphineoxide
« Reply #7 on: October 13, 2006, 09:11:44 AM »
u can use diethyl ether and keep the mixture overnight in 5 degree centgrate
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