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Topic: Separating methimazole and lactose in aqueous solution  (Read 899 times)

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Offline DDAsics

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Separating methimazole and lactose in aqueous solution
« on: January 27, 2020, 06:19:54 AM »
I was hoping someone here might be able to help. It has been years since I took chemistry. I have a protocol that requires around 1g of methimazole powder.  The problem is, this powder is not available locally, and since it is classified as a drug I also can not qualify for a license to import it.  Generic 10mg methimazole tablets are easily available though, and 100 or so tablets would cost only a few dollars, but the issue is how to recover the raw powder from them.

Methimazole is readily dissolved in water, but the tablets also contain lactose as an excipient, which is also readily dissolved in water (as well as basically everything else methimazole can be dissoved in). I am trying to think of some method to precipitate out the lactose so I can create a lypholized methimazole powder.

Does anyone have any suggestions on how I can accomplish this? If there is a better way to accomplish this than dissolving in water please let me know. Thank you for any assistance.

Offline wildfyr

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Re: Separating methimazole and lactose in aqueous solution
« Reply #1 on: January 27, 2020, 02:51:07 PM »
Could you explain what you want it for?

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