November 27, 2024, 08:29:14 PM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: Which of these would react fastest with Ph3P=CH2 in a Wittig Rxn?  (Read 923 times)

0 Members and 1 Guest are viewing this topic.

Offline benzeneluvr765

  • Very New Member
  • *
  • Posts: 1
  • Mole Snacks: +0/-0
Which of these would react fastest with Ph3P=CH2 in a Wittig Rxn?
« on: March 29, 2020, 01:21:44 AM »
Which of the two would react faster in a Wittig Rxn. One has an aldehyde carbonyl the other is a ketone but the ketone has 2 EWGS but probable steric hinderance. Thanks

Logged

Offline pgk

  • Chemist
  • Full Member
  • *
  • Posts: 892
  • Mole Snacks: +97/-24
Re: Which of these would react fastest with Ph3P=CH2 in a Wittig Rxn?
« Reply #1 on: March 30, 2020, 10:46:32 AM »
A ketone reacts slower with a Wittig reagent due to steric hindrance, regardless whether being conjugated or not.
Besides, conjugation deals with the thermodynamic control of the reaction and not with the kinetic control.

« Last Edit: March 30, 2020, 12:10:36 PM by pgk »
Logged
Pages: [1]   Go Up
« previous next »
Sponsored Links