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Topic: N-CBZ protection of S-methyl cystein  (Read 1059 times)

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Offline Bertrand

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N-CBZ protection of S-methyl cystein
« on: March 07, 2022, 11:46:00 AM »
Greetings to everyone here.

I have struggled in making N-CBZ protection of S-methyl cysteine.
Does anyone have a trick for this reaction?
I used a 2M aqueous NaOH solution of S-methyl cysteine and dropwise addition of CBZcl at 0 degrees which did not work. Please I need your help.
Thank you in advance

Looking forward to hearing from you.
Have a nice one.
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Offline rolnor

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Re: N-CBZ protection of S-methyl cystein
« Reply #1 on: March 08, 2022, 11:37:22 PM »
I have used NaHCO3/H2O/EtOAc for other amino acids, you need to be carefull with the workup, its a polar product. This is standard procedure so you should be able to find a procedure in the literature. Its 30 years since I did this so maybe I remember wrong.
« Last Edit: March 08, 2022, 11:47:34 PM by rolnor »
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Offline Bertrand

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Re: N-CBZ protection of S-methyl cystein
« Reply #2 on: March 23, 2022, 07:59:12 AM »
Thank you very much.
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