Topic: Clemmensen Reduction x Halet (Read 1865 times)

brunnoraawr · « **on:** August 27, 2023, 07:15:04 PM »

Hello it's my first post
I need to make a reduction of Clemmensen on a ketone, but the structure have also a halet group, will Clemmenses reduction affects the halet?

O=C(C1=CC=CC=C1)CCl

Hunter2 · « **Reply #1 on:** August 28, 2023, 02:11:43 AM »

If you check the mechanism, you will see it will also reduce the chloride , similar to a Grignard reaction.

brunnoraawr · « **Reply #2 on:** August 28, 2023, 09:42:56 AM »

Quote from: Hunter2 on August 28, 2023, 02:11:43 AM

If you check the mechanism, you will see it will also reduce the chloride , similar to a Grignard reaction.

Do you have any ideia of what reaction I could use to convert This C=O on CH2 without affect the halet?

rolnor · « **Reply #3 on:** August 28, 2023, 02:47:31 PM »

Is this a practical reaction you want to run? You can buy the product?

brunnoraawr · « **Reply #4 on:** August 29, 2023, 09:22:26 PM »

Quote from: rolnor on August 28, 2023, 02:47:31 PM

Is this a practical reaction you want to run? You can buy the product?

Yes, I want to synth similar compounds, varying the CH2 between Cl and Aromatic

rolnor · « **Reply #5 on:** September 01, 2023, 10:00:55 AM »

But you can buy this?

Topic: Clemmensen Reduction x Halet (Read 1865 times)

brunnoraawr

Clemmensen Reduction x Halet

Hunter2

Re: Clemmensen Reduction x Halet

brunnoraawr

Re: Clemmensen Reduction x Halet

rolnor

Re: Clemmensen Reduction x Halet

brunnoraawr

Re: Clemmensen Reduction x Halet

rolnor

Re: Clemmensen Reduction x Halet

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