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Topic: Removing excess Benzoyl Chloride  (Read 6011 times)

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Offline makfc

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Removing excess Benzoyl Chloride
« on: December 23, 2006, 10:06:57 AM »
Hi friends...!

I proceeded for one reaction in which I had to protect the hydroxy group of p-Hydroxybenzaldehyde thro' acylation with Benzoyl Chloride getting Benzoyloxybenzaldehyde. For this I had to use excess (approx. 1.4 eq.) of Benzoyl chloride for complete acylation using acetone & K2CO3 (approx. 2 eq.).

Now, after the reaction completion, what should I do for removing this excess Benzoyl chloride ?   :o

Pls suggest me.. ::)
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Offline movies

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Re: Removing excess Benzoyl Chloride
« Reply #1 on: December 23, 2006, 01:50:11 PM »
You can usually remove it by flash chromatography.  Benzoyl chloride is remarkably stable.  I've reisolated it after chromatography!
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Offline russellm72

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Re: Removing excess Benzoyl Chloride
« Reply #2 on: December 28, 2006, 11:53:20 AM »
Hi,

Ever thought of using a scavenging resin? If you are going to use the reagent a lot it could be a good idea to get some in.

If not, a siliga plug should suffice or a flash column if your crude compound not sufficiently pure.

R.
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