[ayumi]

what is the disadvantage of using 3,4-dihydri-2H-pyran as alcohol protecting group?

[russellm72]

Hi,

Ever thought of reading a book?

perhaps Protecting Groups by P Kocienski.

R.

[miraculix]

@ayumi:
Have you ever seen a NMR-Spectra of a THP-protected alcohol? Due to diastereoisomers it looks like a mess ;-)
You can't tell the "disadvantage", as for example the mild cleaving conditions might be a disadvantage. In a different molecule this is perhaps just the thing you want to have...
So, no general statement can't be given, as far as I'm concerned.


best regards
miraculix