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Topic: Reaction of Sulfuric acid with a carbonyl group  (Read 3112 times)

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Offline desperad0oo7

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Reaction of Sulfuric acid with a carbonyl group
« on: March 05, 2007, 08:32:55 PM »
Hi,

So here is the deal. In the process of L-thyroxin synthesis from l-tyrosine, they form a hydantoin protecting group to hide and stabilize the carboxylic acid and amine functional groups from sulfuric and nitric acids. My question is, what reactions would occur if this ring was not created. afterall, (HSO4-) is a weak nucleophile and I would not expect it to react with the carbon on the carbonyl group. However, I was told otherwise and would like to make sure.

Any suggestions would be greatly appreciated.

Thx

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