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Topic: 3-(2-oxopropyl)cyclohexanone from ethanol and cyclohexanol  (Read 4229 times)

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Offline aleksxxx

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Here is anohter synthesis i was working on for my practice final.

I made the gilman reagent from a grignard w/ methylbromide and acetaldehyde.
The instructions said to use cyclohexanol and ethanol plus any needed reagents, and i used methanol as one of the reagents.
I asked my instructor today and he said i should be able to do it w/ just ethanol - any help here? The hint he gave me was "substituted acetone".

Thanks.

Offline aleksxxx

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Re: 3-(2-oxopropyl)cyclohexanone from ethanol and cyclohexanol
« Reply #1 on: May 02, 2007, 08:34:16 PM »
any one have any ideas on how to do this w/ just ethanol and cyclohexanol?

Offline PRIYA1022

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Re: 3-(2-oxopropyl)cyclohexanone from ethanol and cyclohexanol
« Reply #2 on: May 02, 2007, 09:12:37 PM »
Your synthesis looks pretty good . and the hint about using a substituted acetone.. a silyl enol ether of acetone as an alternative to the gilman reagent  and perform a 1,4- addition on cyclohexenone....Does it look right?

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