December 28, 2024, 05:26:04 PM
Forum Rules: Read This Before Posting


Topic: Can you decarboxylate alpha-hydroxy carboxylic acids with just heat?  (Read 4850 times)

0 Members and 1 Guest are viewing this topic.

Offline Fry

  • Regular Member
  • ***
  • Posts: 60
  • Mole Snacks: +3/-3
Is this possible? I did some searching and only found links with catalysts..

Offline Yarr

  • Regular Member
  • ***
  • Posts: 25
  • Mole Snacks: +2/-0
Re: Can you decarboxylate alpha-hydroxy carboxylic acids with just heat?
« Reply #1 on: September 22, 2007, 05:20:57 PM »
The decarboxylation of alpha-hydroxyacids can be made by heating to ~190ÂșC in what is known as Blaise-Le Sueur degradation. The products are an aldehyde, water, and carbon monoxide: in general, heating RCHOHCO2H will give RCHO + CO + H2O. Here's an old reference for you: J. Chem. Soc., 1904, volume 85, page 827.
Alternatively, this can be done with LTA.

Offline Fry

  • Regular Member
  • ***
  • Posts: 60
  • Mole Snacks: +3/-3
Re: Can you decarboxylate alpha-hydroxy carboxylic acids with just heat?
« Reply #2 on: September 24, 2007, 12:03:36 AM »
Thank you so much!

Sponsored Links