[Butyllithium]

Hi,all,
How long do you take to separate the products from the reaction mixture?There are many separation techniques in organic synthesis ever since, for example,extraction,distillation,crystallization,filtration...and so on.Recently,I have ever read a reference referring to an interesting separation technique in organic synthesis:Magnetic separation.As is reported, a kind of functionalized nano-beads enables you to separate your product from the reaction mixture efficiently and promptly(several minutes). The question is, 1) What's the separation machanism?2)How to produce the nano-beads? 3) How to desorb your desired product from the absorption mixture?
If you have interest in this subject,or if you have any comments, please don't hesitate to contact me.Any help will be appreciated.

Butyllithium
lq.12345@163.com

[IITian]

what sort of magnetic fields are we talking of?

[Arkcon]

There are standard methods for covalently linking a desired ligand to a latex surface.  The use of nanosized magnetic particles to move these latex-coated beads has likewise been around for a while.  The raw materials can be purchased from common chemical suppliers, and they probably provide protocols.  Absorption and desorption can be mediated by ionic strength or pH, for example.  You could also pack them in a tube and have the mixture flow over them, this is called an affinity column.  It sounds like magnets are moving chemicals around, but they aren't really.