[k42490]

My question is: In flushing and cleaning columns used in liquid chromatography to remove absorbed contaminants, a series of solvents is used. Hexane C6H14, chloroform CHCl3, methanol CH3OH, and water are passed through the column in that order. Rationalize the order in terms of intermolecular forces and the mutual solubility of the solvents.

I don't know where to start.

[enahs]

Start with: As the compound is changed, they become more and more polar. Why? What does this do?

[IITian]

you can see that the solvents change from being apolar hexane to being a polar protic solvent (water)