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Topic: simmons-smith cyclopropanation on large scale  (Read 3306 times)

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Offline Sandmeyer

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simmons-smith cyclopropanation on large scale
« on: January 04, 2008, 02:27:32 PM »
Hi everyone,

Do you know any alternative for double bond cyclopropanation (allylic alcohol) that could be eventually scaled up?
Simmons-Smith conditions with expensive CH2I2 and Zn disposals are not feasible enough to be handled on scale.

best regards

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Offline Kryolith

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Re: simmons-smith cyclopropanation on large scale
« Reply #1 on: January 04, 2008, 03:51:36 PM »
Alternatively you could use diazomethane. Since diazoalkanes are explosive, you could also use trimethylsilyldiazomethan (more expensive) for larger scales.
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