4-pyridinecarboxylic acid hydrazine is
pyridine ring with O and NH NH2 on position 4
So you mean like "unknown.gif", in my uploads?
If you mean 4-pyridinecarboxylic acid hydrazide ("Isoniazide.gif") bear in mind there's a carbonyl there not just an ether as your description indicates. How to do it? methyl -> acid as per previous oxidations or SeO
2, then probably acid chloride and hydrazine (careful)
a) Vitamin naicin
b) 3-pyridine carboxylic acid
c) 4-pyridnecarboxylic acid hydrazine
a) 3-pyridine carboxylic acid amide
c) 4-pyridnecarboxylic acid hydrazide
Hmm, seems there's a bit of confusion. Wikipedia suggests niacin is the free acid (
http://en.wikipedia.org/w/index.php?title=Niacin&oldid=195529696, and not just in the English pages), which is what my initial comments were based on, however Joule and Mills (
http://www.amazon.co.uk/Heterocyclic-Chemistry-John-Joule/dp/0632054530/ref=sr_1_3?ie=UTF8&s=books&qid=1204555902&sr=8-3) refer to Niacin as the amide, as per AWK's suggestion (which I thought was nicotinamide).
I guess the two are fairly interconvertible
in vivo?
S