[baseball07]

Hello everyone.  I have these NH2 terminated particles and I was wondering if they would couple to a surface which is terminated in OH, or does the surface have to be a carboxylic acid (carboiimide chemistry)?  Is there any OH/NH2 reaction scheme?  Thanks for your *delete me*

[majorblenks]

hydroxyl is not a particularly good LG at all. if you converted the alcohol to a mesylate or tosylate you'd be able to substitute in the amine. PBr3 (or PPh3/NBS) will lead to bromination with which you could substitute in your amine as well.

hope this helps