[Telamond]

Happy New Years ChemicalForums!

I was wondering what the pros and cons between Internal and External Ionization methods were.

http://www.thermo.com/com/cda/resources/resources_detail/1,2166,11385,00.html says that the external ionization keeps the matrix and neutral compounds from interfering with the compound of interest, and pulled away before detection. This would presumably yield a higher sensitivity.

Internal ionization allows the whole sample to enter the detector, including neutrals, which would result to a much more complex spectra and higher S/N... ()

I'm very uncertain if I've drawn the right conclusions, but if I did, what are then the pros of using an internal ionization source?

[enahs]

Except the fact that you mixed up that a higher Signal to Noise is better.


Claims with instruments are hard to really tell. You have to have experience with them. They all do the same thing, and companies are trying to set themselves apart; is it marketing or is there something substantial to it? Who knows.

Preventing "junk"molecules from entering the ion trap would require less cleaning and possibly prolong the life the instrument as well.

[Telamond]

I think I have some kind of antonym dyslexia... 

Thanks for the help enahs!