[f1987]

I have two question regarding synthesis that I am having trouble with.
Please find these attached; the first I believe I should use the Hantzsch pyridine syntheis, however once I have the product from this I am having trouble with conversion to the required product using the cyclic ketone.
For question two, I can complete the Fischer Indole synthesis but first require the ring ether to be of ketone form for reaction.

Any help much appreciated.

[sjb]

In the second instance can you (on paper) do a retro Fischer to see what your starting material should be me?

The "ring ether" is not actually just an ether though, is it? Do you know about acetals etc.?

[f1987]

Yes, by paper I worked backwards and I think the reactants are Ph-NH-NH2 and CH3C=OCH2CH2OH,  the only way I can think to open the ring i via nuc attack to get an alcohol grown(ie the latter above) yet this doent seem to work.