[olatomide]

i have been trying to synthesize chalcones of 2-hydroxyacetophenone by Claisen Schmidt condensation using different substituted benzaldehyde. After stoping the reaction, i usually acidify aand then dilute with water but the product doesn't crystallize out of the solution.

I normally start the reaction with minimal amount of solvent (ethanol), i see something that looks like  a product that dissolves upon acidification.

Please i need advice on what to do

[russellm72]

Have you tried extracting a portion of your material with EtOAc and running analytical tests to see if you actually have the product in there?

If your not on a huge scale you could always just extract the whole lot and try and recrystallise the crude product.

1st. Make sure your desired product is in there.

Regards

R.

[sjb]

As suggested at http://www.chemicalforums.com/index.php?topic=32312.msg123580 , is there not a danger that your phenolic group is interfering with the synthesis?

What evidence do you have that you have the desired product is actually present?

S