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Topic: chalcone synthesis  (Read 3501 times)

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Offline olatomide

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chalcone synthesis
« on: March 25, 2009, 04:29:38 PM »
how can i react 2-hydroxyacetophenone with 4-dimethylaminobenzaldehyde and get a high yield of the product?
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Offline nj_bartel

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Re: chalcone synthesis
« Reply #1 on: March 26, 2009, 01:06:59 AM »
TMS the alcohol, 1:1 LDA the acetophenone at dry ice temp, add the aminobenzaldehyde, hydrolyze w/2 equivs H2SO4, treat with sacrificial base?
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