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Topic: Difference between oxycodone and hydrocodone  (Read 7353 times)

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Offline jkm89

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Difference between oxycodone and hydrocodone
« on: June 11, 2009, 09:21:56 PM »
What is the difference between oxycodone and hydrocodone? I know there is an extra OH group that comes off of oxycodone, but why does this make it a stronger opiate?
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Offline AWK

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Re: Difference between oxycodone and hydrocodone
« Reply #1 on: June 12, 2009, 02:53:52 AM »
Check both terms on wikipedia
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Offline limpet chicken

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Re: Difference between oxycodone and hydrocodone
« Reply #2 on: June 14, 2009, 11:33:58 AM »
AFAIK its largely because the -OH group is a large, polar zit on hydrocodone's face, and won't pass the BBB so easily as will oxy, as well due to being less lipophillic than the ox.
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Offline jkm89

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Re: Difference between oxycodone and hydrocodone
« Reply #3 on: June 14, 2009, 02:36:01 PM »
No, the OH group is on oxycodone.
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