Topic: How to synthesise 1-bromo-3-chloro-benzene? (Read 25040 times)

Janey · « **Reply #15 on:** June 07, 2005, 02:33:29 PM »

Thank you very much folks

Even though I'm yet not totally sure, I think it will do for a start. Additionally, I asked a Doctor of Chemistry today, as soon as the reply returns I'll post it

And btw:
http://chemistry.boisestate.edu/rbanks/organic/mc/advanced%20problems/elec_sub_unsat/elec_sub_unsat.htm

hmx9123 · « **Reply #16 on:** June 09, 2005, 05:44:45 PM »

This is a bit late, but if you react a Grignard with an electrophilic source of NO₂ ⁺, you will wind up with a mixture of products (-NO₂, -ONO). You could concieveably do a Friedels-Crafts type nitration (so named by Olah), with a lewis acid catalyst like AlCl₃ or TiCl₄ and NO₂Cl. That's some nasty stuff, though.

Donaldson Tan · « **Reply #17 on:** June 12, 2005, 04:52:37 PM »

:thmbup: to Dr HMX. LOL

Mitch · « **Reply #18 on:** June 12, 2005, 06:30:56 PM »

Not quite a doctor as yet.

AWK · « **Reply #19 on:** June 13, 2005, 01:37:16 AM »

1. Nitration to m-dinitrobenzene
2. selective reduction of one nitro group (NaHS)
3. diazotization
4. Sandmayer's reaction
5. reduction
6. diazotization
7. Sandmayer's reaction

Topic: How to synthesise 1-bromo-3-chloro-benzene? (Read 25040 times)

Janey

Re:How to synthesise 1-bromo-3-chloro-benzene?

hmx9123

Re:How to synthesise 1-bromo-3-chloro-benzene?

Donaldson Tan

Re:How to synthesise 1-bromo-3-chloro-benzene?

Mitch

Re:How to synthesise 1-bromo-3-chloro-benzene?

AWK

Re:How to synthesise 1-bromo-3-chloro-benzene?

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