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Topic: Exercise organic  (Read 2703 times)

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Offline darkness1102

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Exercise organic
« on: March 24, 2010, 02:32:59 AM »
Some one anwsers my question?

Offline sjb

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Re: Exercise organic
« Reply #1 on: March 24, 2010, 02:57:55 AM »
Write step 1 out in full. Is there any other product than the amide?

Offline pacifyer

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Re: Exercise organic
« Reply #2 on: April 01, 2010, 12:55:58 PM »
A) You'll need A BASE to remove HCl. Otherwise, only a 50% max yield will be obtained.  :'(

Offline cananian

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Re: Exercise organic
« Reply #3 on: April 04, 2010, 12:22:23 AM »
a] you need both dry condition to avoid hydrolysis of acid chloride
 and you need a base (such as pyridine)as well, just to trap the HCl and thus preventing revrsible reaction
 
b] You can do that, but it will be at the expenss of yield(very low), moreover the acid will protonate the aniline's nitrogen more than the oxygen one, that defenitly will weak the nucleophilicity of nitrogen to attack the carbonyl

c] the best ratio is 2 (amine): 1 alkyl halide

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