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Topic: polymer synthesis  (Read 3150 times)

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Offline nitixa

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polymer synthesis
« on: June 29, 2010, 05:31:38 AM »
Hi,

i am working on polymer synthesis. it's conjugation of drug with biodegradable polymer. In this reaction DCC/DMAP used as catalyst.

But the problem is the final product containing the Residual DMAP which is not removed during the purification process. pl guide me.

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Offline nitixa

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Re: polymer synthesis
« Reply #1 on: June 29, 2010, 07:07:41 AM »
xxx
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Offline Doc Oc

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Re: polymer synthesis
« Reply #2 on: June 29, 2010, 08:08:31 AM »
Generally a simple wash with 1M HCl is enough to get DMAP out, but if your product has a free amine on it that could pose a problem.  You will need to say more about what you made so we can take those things into account as well.
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Offline nitixa

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Re: polymer synthesis
« Reply #3 on: June 30, 2010, 12:38:58 AM »
Thank u for your response.

Actually, our polymer product is used as controlled drug delivery vehicle on stent.

for this product we use the heparin drug & poly L-Lactide Biodegradable polymer.

Heparin -conjugated PLA was prepared by a direct coupling reaction using DCC/DMAP chemistry.

(Thanks for advance)

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