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Topic: Gilbert-Seyferth vs. Ohira-Bestmann?  (Read 2849 times)

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Offline james_a

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Gilbert-Seyferth vs. Ohira-Bestmann?
« on: August 31, 2010, 10:25:25 PM »
Anyone have experience with either of these two alkynlation protocols and could mention the merits/disadvantages of one versus the other? Thanks.
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Offline discodermolide

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Re: Gilbert-Seyferth vs. Ohira-Bestmann?
« Reply #1 on: September 01, 2010, 12:28:56 AM »
It depends a lot on your substrate structure but I like the Bestmann process as it is milder and the side products are easier to remove. You could also try the Corey-Fuchs procedure
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