Hi everyone,
I'm looking for a new method development approach or unconventional for GC quantitation method. We have 9 compounds to analyse simultaneously and I'm wondering if RRF (slope A/slope B) can be used for indirect quantitation? The goal would be to light the working standard preparation. For example, we would use an ethanol standard to quantify a mixture of ethanol, acetone and acetonitrile by direct quantitation for ethanol but indirect quantitation for acetone and acetonitrile using their respective RRF. Method would be validated using both calculation technics to prove equivalency but I'm wondering if this uncommon approach was seen in the past and if you have seen reference for this approach.
Regards