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Can anyone help me with the following, the pKa of pyroglutamaic acid and the pKa of isoaspartic acid? Thanks :-)

pKa of pyroglutamaic acid
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pKa of isoaspartic acid
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Topic: pKa of pyroglutamic acid and isoaspartic acid  (Read 4750 times)

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Offline star12345

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pKa of pyroglutamic acid and isoaspartic acid
« on: October 12, 2010, 05:03:42 AM »
Hi, does anyone know the pKa of pyroglutamaic acid and the pKa of isoaspartic acid? Thanks
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Offline majorjp

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Re: pKa of pyroglutamic acid and isoaspartic acid
« Reply #1 on: October 28, 2010, 06:04:05 AM »
Pyroglutamic acid has the pKa values of: -1.76, 3.48, 12.76
As for isoaspartic acid the pKa value are roughly the same as the pKa values for aspartic acid being as the linkage in the polymer chain is merely change to the beta-carboxyl group from the alpha-carboxyl group, there the pKa values are:~2.10, 3.86, 9.82
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