[smojaz101]

i performed an experiment and i'm expected to give in a full detailed repor, i kinda need some help in my discussion tho,
so please, this is really something i have to present, i just want to know what other ideas are there.
Q
1). discuss the effect of halogen substitution eg(CH2ClCO2H) on the acid strength.
2). in some enzymes, the acidity of certain residues associated with the active site differs from that of other similar residues in the molecule. consider the reason(s) for this, and its importance in determinig the catalytic properties of the enzyme. (example: serine proteases.)

any opinion would be gratefully noted, thanks guys.

[Cherriyan]

For the first part, I would say on any molecule such as CH₂ClCOOH, if the halogen Cl is substituted by any other halogen, then the relative acidity depends upon the -I effect (where I stands for inductive). Say, if Cl is replaced by F, acidity increases, while it decreases if Br replaces Cl (F exerts a more powerful -I effect than Cl, whereas Br exerts a less prominent -I effect than Cl).
Sorry, I have no idea about the second part!