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Topic: Natural product synthesis  (Read 3899 times)

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Offline Nicolas88

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Natural product synthesis
« on: December 12, 2010, 11:34:05 PM »
Does anyone know the biosynthesis of this natural product? or at least its name.. ???
it is in the polyketides synthesis chapter and the doctor gave us a hint that we will need to start with something other than malonyl CoA.

Offline Nicolas88

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Re: Natural product synthesis
« Reply #1 on: December 13, 2010, 08:31:19 AM »
iam trying to solve it but i always stop at this , i just dont know how to connect the fatty acid with the carboxylic acid and the methyl , can anyone give me a hint on this last step?!

Offline Hybrid

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Re: Natural product synthesis
« Reply #2 on: December 13, 2010, 08:38:57 AM »
why u think in methylbenzoic instead of hydroxymethylbenzoic, it is butyrolactone derivative ??

Offline Nicolas88

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Re: Natural product synthesis
« Reply #3 on: December 13, 2010, 10:10:37 AM »
because u cant get a hydroxymethylbenzoic when your synthesizing from acetyl-CoA and Malonyl-CoA either in aldol or claisen condensation.

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