December 22, 2024, 12:33:39 AM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: Conversion of thiourea to urea  (Read 6076 times)

0 Members and 1 Guest are viewing this topic.

Offline Silden

  • New Member
  • **
  • Posts: 3
  • Mole Snacks: +0/-0
Conversion of thiourea to urea
« on: March 27, 2011, 10:33:46 AM »
When I am reacting an amine with isothiocyanate in THF I get both the urea and thiourea products. But when the reaction is performed in DCM only the thiourea is obtained.

Can someone help me with a possible reaction mechanism for the conversion of thiourea to urea in the presence of isothiocyanate and THF (not dry - may contain water)
Logged

Offline Honclbrif

  • Chemist
  • Full Member
  • *
  • Posts: 659
  • Mole Snacks: +58/-10
  • Gender: Male
Re: Conversion of thiourea to urea
« Reply #1 on: March 27, 2011, 12:11:10 PM »
Do you smell any H2S? It may just be a standard aqueous hydrolysis reaction. Water acts as a nucleophile, tetrahedral intermediate, collapse eliminates hydrogen sulfide.
Logged
Individual results may vary
Pages: [1]   Go Up
« previous next »
Sponsored Links