[mstout]

I'm working on a synthesis and stopped at 3-bromo acetophenone. Is it possible to reduce the ketone without affecting the bromine? Clemmensen's or H2/Pd maybe?

My notes from class and book do not show a reduction method being performed on a molecule containing a halogen.

Thank you.

[discodermolide]

I'm working on a synthesis and stopped at 3-bromo acetophenone. Is it possible to reduce the ketone without affecting the bromine? Clemmensen's or H2/Pd maybe?

My notes from class and book do not show a reduction method being performed on a molecule containing a halogen.

Thank you.

Red-Al, li/NaBH3 etc

[nox]

By reduce do you mean reducing it to the alcohol or removal of the functionality completely?

Because there's plenty of ways to do the former, you could probably just hit it with NaBH4 and the reaction will go. If it's the latter, you could probably try a Wolff-Kishner reduction on such a simple substrate.