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Topic: Increasing aqueous solubility of drugs  (Read 4505 times)

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Offline nubee1

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Increasing aqueous solubility of drugs
« on: March 27, 2011, 03:45:34 PM »
I'm stuck on a question...suggest ways of modifying ibuprofen and amantadine structures to increase aqueous solubility.

TIA  ???
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Offline Fluorine

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Re: Increasing aqueous solubility of drugs
« Reply #1 on: March 27, 2011, 06:05:34 PM »
Convert them into their respective salt forms, eg. hydrochloride and sodium or lysine.
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Offline nubee1

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Re: Increasing aqueous solubility of drugs
« Reply #2 on: March 28, 2011, 10:06:09 AM »
thanks for that, whayt about adding OH or a carboxyl group onto the molecule??
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Offline Fluorine

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Re: Increasing aqueous solubility of drugs
« Reply #3 on: March 30, 2011, 10:58:33 PM »
Those should help but it would no longer be ibuprofen or amantadine.
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