December 23, 2024, 02:26:22 AM
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Topic: Problem of the week 14/01/12  (Read 12126 times)

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Offline azmanam

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Re: Problem of the week 14/01/12
« Reply #15 on: January 18, 2012, 04:39:15 PM »
Nice.  I thought about a second lactone opening pathway, but saw the 5-endo and went intermolecular.  I didn't think about epoxide 7.
Knowing why you got a question wrong is better than knowing that you got a question right.

Offline Honclbrif

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Re: Problem of the week 14/01/12
« Reply #16 on: January 18, 2012, 10:17:39 PM »
I always screw up the endo/exo thing when it comes to epoxides and was messing around with 4 in acid. I do not know where to hide my face.

Congrats to azmanam on solving this one. I tip my hat, sir.

I must say Dan, this was a fine problem, even though some parts were a serious Payne. I look forward to tackling future POTWs.
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Offline Guitarmaniac86

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Re: Problem of the week 14/01/12
« Reply #17 on: January 23, 2012, 04:25:24 PM »
This is the kind of thing the post grads do with the lecturers at my uni. Every week we try and crack a synthesis from a paper that has been published. Who ever cracks the synthesis gets to find a paper with an interesting synthesis.

However, I didnt get this at all.
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