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Topic: coupling reaction  (Read 4105 times)

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Offline gopinathsci

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coupling reaction
« on: January 31, 2012, 12:06:15 PM »
can i use CDI instead of DCC for amide bond formation coupling reaction??
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Offline Dan

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Re: coupling reaction
« Reply #1 on: January 31, 2012, 12:28:59 PM »
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Offline OC pro

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Re: coupling reaction
« Reply #2 on: February 01, 2012, 01:57:08 PM »
DCC and the corresponding urea are toxic compounds. CDI is the less toxic variant.
I can also recommend T3P. Works excellent, no racemisation/epimerisation.
http://www.archimica.com/PDF/ARCHIMICA_T3P_Brochure.pdf
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