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Topic: Mechanism of base-catalyzed hydrolysis of amides.  (Read 3381 times)

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Offline tasnim rahman

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Mechanism of base-catalyzed hydrolysis of amides.
« on: May 05, 2012, 10:17:42 AM »
What is the mechanism of the base-catalyzed hydrolysis of amides? It probably starts with OH- attacking the carbonyl carbon. But I have no idea what happens next.  :P
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Offline orgopete

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Re: Mechanism of base-catalyzed hydrolysis of amides.
« Reply #1 on: May 05, 2012, 06:18:36 PM »
Hint, it is a dianion. Then the weakest base is eliminated.
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Offline tasnim rahman

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Re: Mechanism of base-catalyzed hydrolysis of amides.
« Reply #2 on: May 08, 2012, 12:20:57 PM »
Sorry for the late reply. I found this file on the net. Search with "Reaction with Basic H2O - Amides" in the file.

 Is this what you're talking about?
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