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Topic: New total synthesis of cocaine  (Read 15052 times)

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Offline Mitch

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New total synthesis of cocaine
« on: October 02, 2004, 06:09:41 PM »
There's a new total synthesis of (+)-cocaine that just came out in org.lett . My apologies for those that don't have access. http://pubs.acs.org/cgi-bin/article.cgi/orlef7/2004/6/i19/pdf/ol048777a.pdf
« Last Edit: April 27, 2005, 07:00:30 PM by Mitch »
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Re:New total synthesis of cocaine
« Reply #1 on: October 03, 2004, 04:59:01 PM »
Could you post the article? or even if you can't could you PM it me? I would find it really interesting, then  I can see if it is on Rhodium's site already ;D

Offline movies

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Re:New total synthesis of cocaine
« Reply #2 on: October 03, 2004, 05:51:57 PM »
That's pretty cool.  I wonder if you could get to that intermediate 12 by doing a pyrrole Diels-Alder.  What do you all think?

Offline limpet chicken

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Re:New total synthesis of cocaine
« Reply #3 on: December 01, 2005, 08:08:07 PM »
Mitch, I really would be most grateful if you could perhaps email me the PDF, I think information should be free, thats one thing I hate about journals, I can never get journal refs, hell, I can barely afford chemicals, and save for months for new glassware, as all I get is jobseeker's benefit :'(

Consider this an online version of bending down and pleading humbly for a copy of that article.

If you could, then my most sincere thanks.

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Offline mike

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Re:New total synthesis of cocaine
« Reply #4 on: December 01, 2005, 08:13:02 PM »
Quote
I think information should be free

why should this be free? A lot of money, time and effort goes into research, surely you can't expect it to be given away for free??
There is no science without fancy, and no art without facts.

Offline mike

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Re:New total synthesis of cocaine
« Reply #5 on: December 01, 2005, 08:16:50 PM »
Quote
I can get the article but I need the right info ...such as name of article , vol. page. year....java

What do you mean, you can get the article?? All the info is there already!?!?!?!

How do you usually track down journal articles?
There is no science without fancy, and no art without facts.

Offline limpet chicken

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Re:New total synthesis of cocaine
« Reply #6 on: December 01, 2005, 08:27:44 PM »
I believe ALL information should be free and unrestricted, impeding the flow of knowledge, or profiting from it, is, in my opinion, and immoral and disgusting thing to do, it hinders the progress of mankind.

It is akin to a child saying "I know something you don't know, give me your candy and I will tell you"
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Offline mike

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Re:New total synthesis of cocaine
« Reply #7 on: December 01, 2005, 08:36:39 PM »
Quote
had the author of the thresd bothered to list the name of the article , and pertinent info we wouldn't be having this exchange

yes the initial post does contain all of the information you need to find the journal, go to your local university library and you will find it.

Quote
It is akin to a child saying "I know something you don't know, give me your candy and I will tell you"

good call :) I agree with you in some respects, but unfortunately without money it is hard to do research. someone has to publish the journal etc etc there is a lot of infrastructure behind this "information" which is not cheap.


Quote
I believe ALL information should be free and unrestricted, impeding the flow of knowledge, or profiting from it, is, in my opinion, and immoral and disgusting thing to do, it hinders the progress of mankind.

I can sympathise to a point with this, however trade is a fact of life now, whether it is for material goods or information. Hindering the progress of mankind?? all depends on where you think we should be progressing to, so not everyone would agree with you on that one....
There is no science without fancy, and no art without facts.

Offline Mitch

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Re:New total synthesis of cocaine
« Reply #8 on: December 01, 2005, 08:37:42 PM »
This DOI link will get the requisite author, year, blah..blah...blah http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ol048777a
« Last Edit: December 01, 2005, 08:38:56 PM by Mitch »
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Offline mike

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Re:New total synthesis of cocaine
« Reply #9 on: December 01, 2005, 08:40:40 PM »
Quote
as i don't see what vol. or page and title ...do you?

yes.

In the original post I can see:

the name of the journal
the year
the volume
the issue
and most of the title of the article
There is no science without fancy, and no art without facts.

Offline limpet chicken

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Re:New total synthesis of cocaine
« Reply #10 on: December 01, 2005, 10:49:28 PM »
Mitch, if you read this, I know I have no RIGHT to request this, but I will suggest it, perhaps Java could be given access to the chemist forum, he is a long standing, and very responsible member of sciencemadness.org and two other chemistry websites, and has done a lot of very admirable work in collecting references and journal information, and I humbly make the suggestion that he be allowed to access that forum.

Lestat.
« Last Edit: December 02, 2005, 12:26:59 AM by Mitch »
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Offline Mitch

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Re:New total synthesis of cocaine
« Reply #11 on: December 02, 2005, 12:28:54 AM »
The staff and Chemists are a bit liberal with the discussions and copyrights that get discussed in the Chemist forum, more vetting is needed than a days worth of posts about cocaine synthesis.
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Offline limpet chicken

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Re:New total synthesis of cocaine
« Reply #12 on: December 03, 2005, 07:51:51 PM »
Heh, Mitch, I see where your coming from ;)

It was only a suggestion, I just already happened to know of him from Sciencemadness.org and two other sites.
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Offline Donaldson Tan

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Re:New total synthesis of cocaine
« Reply #13 on: December 04, 2005, 03:01:10 AM »
Total Synthesis of (+)-Cocaine via Desymmetrization of a meso-Dialdehyde
Douglas M. Mans and William H. Pearson
Org. Lett.; 2004; 6(19) pp 3305 - 3308; (Letter) DOI: 10.1021/ol048777a
"Say you're in a [chemical] plant and there's a snake on the floor. What are you going to do? Call a consultant? Get a meeting together to talk about which color is the snake? Employees should do one thing: walk over there and you step on the friggin� snake." - Jean-Pierre Garnier, CEO of Glaxosmithkline, June 2006

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