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Topic: Removing Carbodiimide Bonds  (Read 1765 times)

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Offline david0925

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Removing Carbodiimide Bonds
« on: September 27, 2012, 11:38:04 AM »
Hi all,

I am wondering if there are ways of breaking off the carbodiimide crosslinks formed using EDC-NHS, particularly through high pH (>14).

Thank you.
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Offline mamid

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Re: Removing Carbodiimide Bonds
« Reply #1 on: September 28, 2012, 09:24:34 AM »
Could you be just a little more specific?
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Offline Babcock_Hall

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Re: Removing Carbodiimide Bonds
« Reply #2 on: September 28, 2012, 10:30:41 AM »
Can you provide a structure?
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Offline discodermolide

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Re: Removing Carbodiimide Bonds
« Reply #3 on: September 28, 2012, 10:33:21 AM »
You could try heating in 30% NaOH solution. Although it it hard to suggest anything without some structural info.
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