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Topic: HATU  (Read 2060 times)

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Offline Super Newb

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HATU
« on: September 08, 2012, 05:18:35 AM »
I am doing a amide coupling and wondering if a minute amount of (HATU ~14mg) is soluble in ethanol. Much thanks :) Any other advice will be appreciated :)
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Offline NotExactly

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Re: HATU
« Reply #1 on: September 27, 2012, 08:18:06 PM »
HATU should go into EtOH fine, but I don't think using ethanol or any alcohol as a solvent would be a good idea because you will probably make a large quantity of the ethyl ester of your acid.  Typically amide couplings are done in DMF
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