[BulletproofHeart]

How can this compound be made? I'm not familiar with the SO₂Tol moiety and I'm really stuck. I can't use retrosynthesis properly.

[discodermolide]

Well if you are starting with the amine, us should use Toluene sulfonyl chloride to alkylate the nitrogen. This can be done in dichloromethane with triethylamine as a base, or any other tertiary amine.
If you need a retro-synthesis for the whole molecule that's a different question!